PHA 4210 Course Coordinator:
Section Coordinators:
Medicinal Chemistry:
Other Course Instructors:
George Allen, Pharm.D., Infectious Diseases Research Fellow, phone: 745-9130, E-mail: gallen@hotmail.com
Ronda Akins, Pharm.D., Infectious Diseases Research Fellow, phone: 745-9130, E-mail: rakins@dmc.org
Elizabeth Coyle, Pharm.D. Infectious Diseases Research Fellow, phone:745-9130, E-mail: ecoyl@dmc.org
Peggy McKinnon, Pharm.D., Clinical Assistant Professor of Pharmacy Practice, phone: 966-0464, E-mail: pmckinno@dmc.org
Polly Kintzel, Pharm.D. Clinical Assistant Professor of Pharmacy Practice, phone: 966-7883, E-mail: ???
Web-Based Instructional Materials:
Textbooks:
1. Pharmacotherapy: A Pathophysiologic Approach. DiPiro 4rd Edition. (Required).
2. Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. Delgrado and Remers 9th Edition. (Optional).
3. Human Pharmacology, Molecular to Clinical. Wingard, Brody, Larner, Schwartz. (Optional).
This is a six week six credit hour module designed to provide the student with a general understanding of the medicinal chemistry and pharmacology of anti-infectives and the pathophysiology and therapeutic management of commonly encountered infections and dematologic diseases.
Assigned Reading and Homework
Students are responsible for the material in Pharmacotherapy: A pathophysiologic approach in the corresponding chapters to the topics of each lecture title. Some questions on the exams will cover material assigned in the book that was not reviewed in lecture. Material may be presented in case or lecture format and may vary with instructors. It is the student's responsibility to read all assignments prior to class.
Class material and homework assignments will be placed on the web page for students to access and complete. Homework will be assigned for each module and is worth 10% of the final grade. Homework for each weekly module must be handed in (hard copy) to the instructor during the final lecture on Thursday of each week.
Discussion Sessions
The discussions sessions scheduled for Modules 2-6 every Monday from 11:15-1:15. This time period is to be used to present cases emphizing information presented in class. This time may also be used to ask faculty any questions students may have regarding material previously presented.
Therapeutics Course Objectives
After attending the therapeutic infectious diseases lectures the student should be able to:
1. Discuss the epidemiology and pathophysiology of the various disease states presented in class.
2. Identify laboratory and diagnostic tests which are used in the diagnosis and evaluation of the various infections and dermatologic problems discussed in class.
3. Utilize patient specific parameters to develop or change a therapeutic plan for management of infectious diseases and dermatologic diseases.
4. Choose the most appropriate anti-infective regimen including dosages and duration of therapy for empiric or definitive treatment for specific pathogens and their related infections.
5. Identify and interpret subjective and objective data for assessing the clinical effects of anti-infective therapy for the various infections discussed in class.
6. Choose the most appropriate dermatologic agent including dosages, route of administration, duration of therapy for each of the various dermatologic problems presented in class.
7. Identify changes in organ function which may alter drug disposition and recommend appropriate alterations to the drug therapy as a result of the change in organ function.
8. Identify the presence of adverse effects and drug interactions involving anti-infectives and dermatologic agents and make recommendations to minimize the impact of these reactions.
9. Select therapeutic endpoints for treatment based upon patient clinical response and literature based guidelines.
Medicinal Chemistry Course Objectives
1. The student will gain an appreciation of the structure-activity relationships of the various classes of anti-infectives and dermatological agents discussed in class.
2. The chemical features which govern the pharmacokinetic and stability of various dosage forms will be discussed.
3. The student will know the mechanism(s) of action and toxicities of the various classes of anti-infectives and dermatological agents.
Grading Policy
Your course grade will be based on your performance on six examinations, and homework problems. Each exam is based upon the material presented for the specific module. Homework problem sets will be placed on the web page. Homework assignments are worth 10% of the total grade.
If you have a compelling reason for missing an examination, please notify Dr. Rybak or Dr. Cappelletty or Dr. Singh before the examination so that arrangements for a makeup can be made. An un-excused absence from an examination will result in the assignment of a grade of zero for that examination. Final grades will be based on the distribution of cumulative point totals at the end of the semester; thus, a grading scale will not be established until the course has been completed and all examinations have been graded. Each student will then be assigned a letter grade of "A", "B", "C" or "E" (there will be no "D" grades assigned).
Academic Dishonesty
A practicing Pharmacist must be able to be trusted to regulate the dispensing of controlled substances and to enforce all laws pertaining to the ethical dispensing of medication. If you feel that cheating on examinations is the only way for you to pass courses and obtain a Pharmacy degree, you have aspired to the wrong profession. Any student caught cheating will be dealt with according to the University Due Process Statute, Section 10:
"In any instance of academic dishonesty occurring in this course as defined in Section 3.0 of the University Due Process Statute, the provisions of 10.0 of the Statute will be implemented as follows: The grade for the course will be reduced to an "E". In addition, charges MAY be filed, asprovided for in Section 10.2 of the Statute, which may lead to further sanctions up to and including expulsion from the College or the University."
Note: The policy outlined above will be strictly enforced! Anyone who is caught cheating in any fashion on an examination or quiz will be removed from the room immediately, and their paper will be confiscated. You worked hard to get in to Pharmacy school - don't risk exclusion from the program by trying to take the easy way out!
| Day/Date | Time | Topic | Instructor | |
|---|---|---|---|---|
| Module Section I | ||||
| Mon. 1/10 | 8:00 - 8:15 | General Announcements/Syllabus | Rybak | |
| Mon. 1/10 | 8:20 - 10:00 | Microbiology | Cappelletty | |
| Mon. 1/10 | Microbiology | Cappelletty | ||
| Tues. 1/11 | 8:00 - 10:00 | Microbiology | Cappelletty | |
| Tues. 1/11 | 11:15 - 13:15 | Microbiology | Cappelletty | |
| Tues. 1/11 | 13:25 - 15:25 | Microbiology | Cappelletty | |
| Wed. 1/12 | 8:00 - 10:00 | Microbiology | Cappelletty | |
| Wed. 1/12 | 11:15 - 13:15 | Microbiology | Cappelletty | |
| Thurs. 1/13 | 8:00 - 10:00 | Microbiology | Cappelletty | |
| Thurs. 1/13 | 11:15 - 13:15 | Microbiology | Cappelletty | |
| Fri. 1/14 | --- | Study Day | --- | |
| Mon. 1/17 | --- | Martin Luther King Day | No Class | |
| Tues. 1/18 | 8:00 - 10:00 | Exam 1 | Cappelletty | |
| Module Section II | ||||
| Tues. 1/18 | 11:15 - 13:15 | Microbiology | Cappelletty | |
| Tues. 1/18 | 13:25 - 15:25 | Microbiology | Cappelletty | |
| Wed. 1/19 | 8:00 - 10:00 | General Principles of Infectious Disease | Rybak | |
| Wed. 1/19 | 11:15 - 13:15 | Antibiotic Discovery/Beta Lactams I | Kerns | |
| Thurs. 1/20 | 8:00 - 10:00 | Beta Lactams II/Glycopeptides/Allergy | Kerns | |
| Thurs. 1/20 | 11:15 - 13:15 | Sulfas, Macrolides, Streptogranins, Tetracyclines | Gibbs | |
| Fri. 1/21 | --- | Study Day | --- | |
| Mon. 1/24 | 8:00 - 10:00 | Aminoglycosides, Quinolones | Gibbs | |
| Mon. 1/24 | 11:15 - 13:15 | Discussion Session | Faculty | |
| Tues. 1/25 | 8:00 - 10:00 | Exam 2 | Cappelletty | |
| Module Section III | ||||
| Tues. 1/25 | 11:15 - 13:15 | Pharmacokinetics I | Cappelletty | |
| Tues. 1/25 | 13:25 - 15:25 | Pharmacokinetics II | Cappelletty | |
| Wed. 1/26 | 8:00 - 10:00 | Antimicrobial Pharmacodynamics and Selection | Rybak | |
| Wed. 1/26 | 11:15 - 13:15 | Urinary Tract Infections | Allen | |
| Thurs. 1/27 | 8:00 - 10:00 | Pneumonia | Rybak | |
| Thurs. 1/27 | 11:15 - 13:15 | Bacteremia and Sepsis | Coyle | |
| Fri. 1/28 | --- | Study Day | --- | |
| Mon. 1/31 | 8:00 - 10:00 | Meningitis | Rybak | |
| Mon. 1/31 | 11:15 - 13:15 | Discussion Session | Faculty | |
| Tues. 2/1 | 8:00 - 10:00 | Exam 3 | Rybak | |
| Module Section IV | ||||
| Tues. 2/1 | 11:15 - 13:15 | Endocarditis | Rybak | |
| Tues. 2/1 | 13:25 - 15:25 | Antiprotozoal and Antihelminthic Agents | Kerns | |
| Wed. 2/2 | 8:00 - 10:00 | Sexually Transmitted Diseases | Cappelletty | |
| Wed. 2/2 | 11:15 - 13:15 | Gastrointestinal Infections | Cappelletty | |
| Thurs. 2/3 | 8:00 - 10:00 | Opthalmic & Topical Antibiotics | Gibbs | |
| Thurs. 2/3 | 11:15 - 13:15 | Otitis Media & Opthalmic Infections | Rybak | |
| Fri. 2/4 | --- | Study Day | --- | |
| Mon. 2/7 | 8:00 - 10:00 | Skin/Soft Tissue/Bone & Joint | Rybak | |
| Mon. 2/7 | 11:15 - 13:15 | Discussion Session | Faculty | |
| Tues. 2/8 | 8:00 - 10:00 | Exam 4 | Rybak | |
| Module Section V | ||||
| Tues. 2/8 | 11:15 - 13:15 | Antiuberculosis/Antiviral Agents | Kerns/Gibbs | |
| Tues. 2/8 | 13:25 - 15:25 | Tuberculosis/Viral Infections | Cappelletty | |
| Wed. 2/9 | 8:00 - 10:00 | Antifungal Agents | Gibbs | |
| Wed. 2/9 | 11:15 - 13:15 | Fungal Infections | Akins | |
| Thurs. 2/10 | 8:00 - 10:00 | AIDS I | McKinnon | |
| Thurs. 2/10 | 11:15 - 13:15 | AIDS II | McKinnon | |
| Fri. 2/11 | --- | Study Day | --- | |
| Mon. 2/14 | 8:00 - 10:00 | Immunocompromised Infections | Kinyzel | |
| Mon. 2/14 | 11:15 - 13:15 | Discussion Session | Faculty | |
| Tues. 2/15 | 8:00 - 10:00 | Exam 5 | Rybak | |
| Module Section VI | ||||
| Tues. 2/15 | 11:15 - 13:15 | Dermatology Overview (Skin and Drug Delivery) | Singh | |
| Tues. 2/15 | 13:25 - 14:30 | Drug Induced Skin Disease | Miller | |
| Tues. 2/15 | 14:30 - 15:25 | Acne Vulgaris and Acne Rosacea | Miller | |
| Wed. 2/16 | 8:00 - 10:00 | Dandruff, Seborrheic Dermatitis, Psoriasis | Goldfadden | |
| Wed. 2/16 | 11:15 - 13:15 | External Analgesics | Singh | |
| Thurs. 2/17 | 8:00 - 10:00 | Suntan/Sunburn/Burn/Diaper Rash Products | Suykerbuyk | |
| Thurs. 2/17 | 11:15 - 13:15 | First Aid Products | Suykeybuyk | |
| Fri. 2/18 | --- | Study Day | --- | |
| Mon. 2/21 | 8:00 - 10:00 | Minor Wound Care, Poison Ivy, Oak and Sumac | Lindblad | |
| Mon. 2/21 | 11:15 - 13:15 | Discussion Session | Faculty | |
| Tues. 2/22 | 8:00 - 10:00 | Exam 6 | Singh |