PHA 4140 - Gastrointestinal Pharmacology

Instructor: Robert T. Louis-Ferdinand, Ph.D.

Lecture Outline

1. Gastrointestinal Stimulants (Prokinetics)

a) Metoclopramide (Reglan¨)

b) Dexpanthenol (Lopan¨)

c) Cisapride (Propulsid¨)

2. Muscarinic Antagonists/Anticholinergics/Antispasmodics

a) Antispasmodics

1) Dicyclomine (Bemote¨)

2) Oxphencycimine (Daricon¨)

3. H2 Antagonists

a) Cimetidine (Tagamet¨)

b) Famotidine (Pepcid¨)

c) Nizatidine (Axid¨)

d) Ranitidine (Zantac¨)

4. Pentagastrin (Peptavlon¨)

5. Misoprostol (Cytotec¨)

6. Omeprazole (Prilosec¨)

7. Antacids

a) Systemic

1) Sodium Bicarbonate

a) Non-Systemic

1) Calcium carbonate

2) Magnesium trisilicate

3) Aluminum hydroxide gel

4) Magnesium oxide

5) Magnesium hydroxide

8. Cytoprotectants

a) Sucralfate (Carafate¨)

b) Carbenoxolone (Biogastrone¨)

c) Misoprostol (Cytotec¨)

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